Cardiovascular effects of protamine sulfate: Reply
نویسندگان
چکیده
منابع مشابه
Anticoagulant effects of protamine sulfate in a canine model.
Protamine sulfate is considered a weak anticoagulant, yet little is known concerning the mechanism of this effect or its relation to prior heparin exposure. This investigation defined the influence of increasing doses of protamine, with and without prior heparin anticoagulation, on the activated clotting time (ACT), thrombin clotting time (TCT), prothrombin time (PT), partial thromboplastin tim...
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Superparamagnetic Iron Oxide (SPIO) complexed with cationic transfection agent is used to label various mammalian cells. Labeled cells can then be utilized as an in vivo magnetic resonance imaging (MRI) probes. However, certain number of in vivo administered labeled cells may be cleared from tissues by the host's macrophages. For successful translation to routine clinical application of SPIO la...
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Chondroitin sulfate proteoglycans (CSPGs), which are enriched in demyelinating plaques in neurodegenerative diseases, such as multiple sclerosis (MS), impair remyelination by inhibiting the migration and differentiation of oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS). We herein show that protamine (PRM, also known as a heparin antagonist) effectively neutralizes th...
متن کاملEffect of protamine sulfate on the aca heparin assay.
Fig. 1 . Effect of increasing amounts of protamine sulfate on the ace measurement of hepann in whole blood (1 USP unlt/mL) The protam,ne/hepann ratio is based on the assumption that 0.01 mg of protamine neutralizes 1 unIt of hepaiin. The measured hepaiin concentration is shown as a percent of anti-factor Xa activity relative to baseline (no added protamine) determined in each experiment. The re...
متن کاملCatastrophic cardiovascular adverse reactions to protamine.
The article by Viaro et al1 (September 2002) provides important and interesting data on the side effect profile of protamine. However, their article raises a number of important points that need addressing. First, clinically, when protamine is administered slowly, the vast majority of patients experience a minimal cardiovascular effect. A few individuals show elevated pulmonary artery pressures...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1985
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)38647-7